Small Molecule Mediated Degradation of the Androgen Receptor Through Hydrophobic Tagging

Androgen Receptor (AR)-dependent transcription is a major driver of prostate tumor cell proliferation. Consequently, it is the target of several antitumor chemotherapeutic agents, including the AR antagonist MDV3100/enzalutamide. Recent studies have shown that a single AR mutation (F876L) converts M...

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Udgivet i:Angew Chem Int Ed Engl
Main Authors: Gustafson, Jeffrey L., Neklesa, Taavi K., Cox, Carly S., Roth, Anke G., Buckley, Dennis L., Tae, Hyun Seop, Sundberg, Thomas B., Stagg, D. Blake, Hines, John, McDonnell, Donald P., Norris, John D., Crews, Craig M.
Format: Artigo
Sprog:Inglês
Udgivet: 2015
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4547777/
https://ncbi.nlm.nih.gov/pubmed/26083457
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.201503720
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