Small Molecule Mediated Degradation of the Androgen Receptor Through Hydrophobic Tagging

Androgen Receptor (AR)-dependent transcription is a major driver of prostate tumor cell proliferation. Consequently, it is the target of several antitumor chemotherapeutic agents, including the AR antagonist MDV3100/enzalutamide. Recent studies have shown that a single AR mutation (F876L) converts M...

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Détails bibliographiques
Publié dans:Angew Chem Int Ed Engl
Auteurs principaux: Gustafson, Jeffrey L., Neklesa, Taavi K., Cox, Carly S., Roth, Anke G., Buckley, Dennis L., Tae, Hyun Seop, Sundberg, Thomas B., Stagg, D. Blake, Hines, John, McDonnell, Donald P., Norris, John D., Crews, Craig M.
Format: Artigo
Langue:Inglês
Publié: 2015
Sujets:
Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4547777/
https://ncbi.nlm.nih.gov/pubmed/26083457
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.201503720
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