HaloPROTACS: Use of Small Molecule PROTACs to Induce Degradation of HaloTag Fusion Proteins

Small molecule-induced protein degradation is an attractive strategy for the development of chemical probes. One method for inducing targeted protein degradation involves the use of PROTACs, heterobifunctional molecules that can recruit specific E3 ligases to a desired protein of interest. PROTACs h...

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Publié dans:ACS Chem Biol
Auteurs principaux: Buckley, Dennis L, Raina, Kanak, Darricarrere, Nicole, Hines, John, Gustafson, Jeffrey L, Smith, Ian E., Miah, Afjal H, Harling, John D, Crews, Craig M
Format: Artigo
Langue:Inglês
Publié: 2015
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4629848/
https://ncbi.nlm.nih.gov/pubmed/26070106
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschembio.5b00442
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