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Small-Molecule Hydrophobic Tagging Induced Degradation of HaloTag Fusion Proteins
The ability to regulate any protein of interest in living systems with small molecules remains a challenge. We hypothesized that appending a hydrophobic moiety to the surface of a protein would mimic the partially denatured state of the protein, thus engaging the cellular quality control machinery t...
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| Главные авторы: | , , , , , , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
2011
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3139752/ https://ncbi.nlm.nih.gov/pubmed/21725302 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nchembio.597 |
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