Targeted Protein Degradation Phenotypic Studies Using HaloTag CRISPR/Cas9 Endogenous Tagging Coupled with HaloPROTAC3

To assess the role of a protein, protein loss phenotypic studies can be used, most commonly through mutagenesis RNAi or CRISPR knockout. Such studies have been critical for the understanding of protein function and the identification of putative therapeutic targets for numerous human disease states....

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Shranjeno v:
Bibliografske podrobnosti
izdano v:Curr Protoc Pharmacol
Main Authors: Caine, Elizabeth A., Mahan, Sarah D., Johnson, Rebecca L., Nieman, Amanda N., Lam, Ngan, Warren, Curtis R., Riching, Kristin M., Urh, Marjeta, Daniels, Danette L.
Format: Artigo
Jezik:Inglês
Izdano: John Wiley and Sons Inc. 2020
Teme:
Protocol
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC7818660/
https://ncbi.nlm.nih.gov/pubmed/33332748
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cpph.81
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