Targeted Protein Degradation Phenotypic Studies Using HaloTag CRISPR/Cas9 Endogenous Tagging Coupled with HaloPROTAC3

To assess the role of a protein, protein loss phenotypic studies can be used, most commonly through mutagenesis RNAi or CRISPR knockout. Such studies have been critical for the understanding of protein function and the identification of putative therapeutic targets for numerous human disease states....

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Dettagli Bibliografici
Pubblicato in:Curr Protoc Pharmacol
Autori principali: Caine, Elizabeth A., Mahan, Sarah D., Johnson, Rebecca L., Nieman, Amanda N., Lam, Ngan, Warren, Curtis R., Riching, Kristin M., Urh, Marjeta, Daniels, Danette L.
Natura: Artigo
Lingua:Inglês
Pubblicazione: John Wiley and Sons Inc. 2020
Soggetti:
Protocol
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7818660/
https://ncbi.nlm.nih.gov/pubmed/33332748
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cpph.81
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