Targeted Protein Degradation Phenotypic Studies Using HaloTag CRISPR/Cas9 Endogenous Tagging Coupled with HaloPROTAC3

To assess the role of a protein, protein loss phenotypic studies can be used, most commonly through mutagenesis RNAi or CRISPR knockout. Such studies have been critical for the understanding of protein function and the identification of putative therapeutic targets for numerous human disease states....

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Detalhes bibliográficos
Publicado no:Curr Protoc Pharmacol
Main Authors: Caine, Elizabeth A., Mahan, Sarah D., Johnson, Rebecca L., Nieman, Amanda N., Lam, Ngan, Warren, Curtis R., Riching, Kristin M., Urh, Marjeta, Daniels, Danette L.
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2020
Assuntos:
Protocol
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7818660/
https://ncbi.nlm.nih.gov/pubmed/33332748
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cpph.81
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