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Gene selective mRNA cleavage inhibits the development of Plasmodium falciparum
Unique peptide-morpholino oligomer (PMO) conjugates have been designed to bind and promote the cleavage of specific mRNA as a tool to inhibit gene function and parasite growth. The new conjugates were validated using the P. falciparum gyrase mRNA as a target (PfGyrA). Assays in vitro demonstrated a...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3341008/ https://ncbi.nlm.nih.gov/pubmed/22474358 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1203516109 |
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