2,2,2-Trifluoro-N-(isoquinolin-5-ylmeth­yl)acetamide

Por Kennedy, Alan R., Khalaf, Abedawn I., Suckling, Colin J.
Publicado em 2009

Novel TPP-riboswitch activators bypass metabolic enzyme dependency

Por Lünse, Christina E., Scott, Fraser J., Suckling, Colin J., Mayer, Günter
Publicado em 2014

Crystal structure of N,N-dimethyl-2-[(4-methyl­benz­yl)sulfon­yl]ethanamine

Por Kennedy, Alan R., Khalaf, Abedawn I., Scott, Fraser J., Suckling, Colin J.
Publicado no Acta Crystallogr E Crystallogr Commun (2015)

Four pyrrole derivatives used as building blocks in the synthesis of minor-groove binders

Por Kennedy, Alan R., Khalaf, Abedawn I., Scott, Fraser J., Suckling, Colin J.
Publicado no Acta Crystallogr E Crystallogr Commun (2017)

Small Molecule Analogues of the parasitic worm product ES-62 interact with the TIR domain of MyD88 to inhibit pro-inflammatory signalling

Por Suckling, Colin J., Alam, Shahabuddin, Olson, Mark A., Saikh, Kamal U., Harnett, Margaret M., Harnett, William
Publicado no Sci Rep (2018)

Manganese dioxide mediated one-pot synthesis of methyl 9H-pyrido[3,4-b]indole-1-carboxylate: Concise synthesis of alangiobussinine

Por Baiget, Jessica, Llona-Minguez, Sabin, Lang, Stuart, MacKay, Simon P, Suckling, Colin J, Sutcliffe, Oliver B
Publicado em 2011

Communication between the Zinc and Tetrahydrobiopterin Binding Sites in Nitric Oxide Synthase

Por Chreifi, Georges, Li, Huiying, McInnes, Craig R., Gibson, Colin L., Suckling, Colin J., Poulos, Thomas L.
Publicado em 2014

Protective effect of small molecule analogues of the Acanthocheilonema viteae secreted product ES-62 on oxazolone-induced ear inflammation

Por Al-Riyami, Lamyaa, Rodgers, David T., Rzepecka, Justyna, Pineda, Miguel A., Suckling, Colin J., Harnett, Margaret M., Harnett, William
Publicado no Exp Parasitol (2015)

DNA sequence recognition by an isopropyl substituted thiazole polyamide

Por James, Peter L., Merkina, Elena E., Khalaf, Abedawn I., Suckling, Colin J., Waigh, Roger D., Brown, Tom, Fox, Keith R.
Publicado em 2004

Dendritic cells provide a therapeutic target for synthetic small molecule analogues of the parasitic worm product, ES-62

Por Lumb, Felicity E., Doonan, James, Bell, Kara S., Pineda, Miguel A., Corbet, Marlene, Suckling, Colin J., Harnett, Margaret M., Harnett, William
Publicado no Sci Rep (2017)

An evaluation of Minor Groove Binders as anti-Trypanosoma brucei brucei therapeutics

Por Scott, Fraser J., Khalaf, Abedawn I., Giordani, Federica, Wong, Pui Ee, Duffy, Sandra, Barrett, Michael, Avery, Vicky M., Suckling, Colin J.
Publicado no Eur J Med Chem (2016)

Ranking Ligand Affinity for the DNA Minor Groove by Experiment and Simulation

Por Wittayanarakul, Kitiyaporn, Anthony, Nahoum G., Treesuwan, Witcha, Hannongbua, Supa, Alniss, Hasan, Khalaf, Abedawn I., Suckling, Colin J., Parkinson, John A, Mackay, Simon P.
Publicado em 2010

Protection Against Arthritis by the Parasitic Worm Product ES-62, and Its Drug-Like Small Molecule Analogues, Is Associated With Inhibition of Osteoclastogenesis

Por Doonan, James, Lumb, Felicity E., Pineda, Miguel A., Tarafdar, Anuradha, Crowe, Jenny, Khan, Aneesah M., Suckling, Colin J., Harnett, Margaret M., Harnett, William
Publicado no Front Immunol (2018)

Structure-Based Design of Pteridine Reductase Inhibitors Targeting African Sleeping Sickness and the Leishmaniases

Por Tulloch, Lindsay B., Martini, Viviane P., Iulek, Jorge, Huggan, Judith K., Lee, Jeong Hwan, Gibson, Colin L., Smith, Terry K., Suckling, Colin J., Hunter, William N.
Publicado em 2009

Designing Anti-inflammatory Drugs from Parasitic Worms: A Synthetic Small Molecule Analogue of the Acanthocheilonema viteae Product ES-62 Prevents Development of Collagen-Induced A...

Por Al-Riyami, Lamyaa, Pineda, Miguel A., Rzepecka, Justyna, Huggan, Judith K., Khalaf, Abedawn I., Suckling, Colin J., Scott, Fraser J., Rodgers, David T., Harnett, Margaret M., Harnett, William
Publicado em 2013

Structure-Based Design and Synthesis of Antiparasitic Pyrrolopyrimidines Targeting Pteridine Reductase 1

Por Khalaf, Abedawn I., Huggan, Judith K., Suckling, Colin J., Gibson, Colin L., Stewart, Kirsten, Giordani, Federica, Barrett, Michael P., Wong, Pui Ee, Barrack, Keri L., Hunter, William N.
Publicado em 2014

Evaluation of minor groove binders (MGBs) as novel anti-mycobacterial agents and the effect of using non-ionic surfactant vesicles as a delivery system to improve their efficacy

Por Hlaka, Lerato, Rosslee, Michael-Jon, Ozturk, Mumin, Kumar, Santosh, Parihar, Suraj P, Brombacher, Frank, Khalaf, Abedawn I, Carter, Katharine C, Scott, Fraser J, Suckling, Colin J, Guler, Reto
Publicado no J Antimicrob Chemother (2017)

Small molecule analogues of the immunomodulatory parasitic helminth product ES-62 have anti-allergy properties

Por Rzepecka, Justyna, Coates, Michelle L., Saggar, Moninder, Al-Riyami, Lamyaa, Coltherd, Jennifer, Tay, Hwee Kee, Huggan, Judith K., Janicova, Lucia, Khalaf, Abedawn I., Siebeke, Ivonne, Suckling, Colin J., Harnett, Margaret M., Harnett, William
Publicado em 2014

Prophylactic and therapeutic treatment with a synthetic analogue of a parasitic worm product prevents experimental arthritis and inhibits IL-1β production via NRF2-mediated counter...

Por Rzepecka, Justyna, Pineda, Miguel A., Al-Riyami, Lamyaa, Rodgers, David T., Huggan, Judith K., Lumb, Felicity E., Khalaf, Abedawn I., Meakin, Paul J., Corbet, Marlene, Ashford, Michael L., Suckling, Colin J., Harnett, Margaret M., Harnett, William
Publicado no J Autoimmun (2015)

Inhibitory Kappa B Kinase α (IKKα) Inhibitors That Recapitulate Their Selectivity in Cells against Isoform-Related Biomarkers

Por Anthony, Nahoum G., Baiget, Jessica, Berretta, Giacomo, Boyd, Marie, Breen, David, Edwards, Joanne, Gamble, Carly, Gray, Alexander I., Harvey, Alan L., Hatziieremia, Sophia, Ho, Ka Ho, Huggan, Judith K., Lang, Stuart, Llona-Minguez, Sabin, Luo, Jia Lin, McIntosh, Kathryn, Paul, Andrew, Plevin, Robin J., Robertson, Murray N., Scott, Rebecca, Suckling, Colin J., Sutcliffe, Oliver B., Young, Louise C., Mackay, Simon P.
Publicado no J Med Chem (2017)