Inhibitory Kappa B Kinase α (IKKα) Inhibitors That Recapitulate Their Selectivity in Cells against Isoform-Related Biomarkers

[Image: see text] IKKβ plays a central role in the canonical NF-kB pathway, which has been extensively characterized. The role of IKKα in the noncanonical NF-kB pathway, and indeed in the canonical pathway as a complex with IKKβ, is less well understood. One major reason for this is the absence of c...

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Detalhes bibliográficos
Publicado no:J Med Chem
Main Authors: Anthony, Nahoum G., Baiget, Jessica, Berretta, Giacomo, Boyd, Marie, Breen, David, Edwards, Joanne, Gamble, Carly, Gray, Alexander I., Harvey, Alan L., Hatziieremia, Sophia, Ho, Ka Ho, Huggan, Judith K., Lang, Stuart, Llona-Minguez, Sabin, Luo, Jia Lin, McIntosh, Kathryn, Paul, Andrew, Plevin, Robin J., Robertson, Murray N., Scott, Rebecca, Suckling, Colin J., Sutcliffe, Oliver B., Young, Louise C., Mackay, Simon P.
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2017
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5578373/
https://ncbi.nlm.nih.gov/pubmed/28737909
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.7b00484
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