Isotope-specific and amino acid-specific heavy atom substitutions alter barrier crossing in human purine nucleoside phosphorylase

Por Suarez, Javier, Schramm, Vern L.
Publicado no Proc Natl Acad Sci U S A (2015)

Long-term outcomes after stenting as a “bridge to surgery” for the management of acute obstruction secondary to colorectal cancer

Por Suárez, Javier, Jimenez-Pérez, Javier
Publicado no World J Gastrointest Oncol (2016)

Spin Trapping Investigation of Peroxide- and Isoniazid-Induced Radicals in Mycobacterium tuberculosis Catalase-Peroxidase

Por Ranguelova, Kalina, Suarez, Javier, Magliozzo, Richard S., Mason, Ronald P.
Publicado em 2008

Antibiotic Resistance in Mycobacterium tuberculosis: PEROXIDASE INTERMEDIATE BYPASS CAUSES POOR ISONIAZID ACTIVATION BY THE S315G MUTANT OF M. TUBERCULOSIS CATALASE-PEROXIDASE (Kat...

Por Suarez, Javier, Ranguelova, Kalina, Schelvis, Johannes P. M., Magliozzo, Richard S.
Publicado em 2009

A radical on the Met-Tyr-Trp modification required for catalase activity in catalase-peroxidase is established by isotopic labeling and site-directed mutagenesis

Por Zhao, Xiangbo, Suarez, Javier, Khajo, Abdelahad, Yu, Shengwei, Metlitsky, Leonid, Magliozzo, Richard S.
Publicado em 2010

Interactions of Arene-Ru(II)-Chloroquine Complexes of Known Antimalarial and Antitumor Activity with Human Serum Albumin (HSA) and Transferrin

Por Martínez, Alberto, Suárez, Javier, Shand, Tiffany, Magliozzo, Richard S., Sánchez-Delgado, Roberto A.
Publicado em 2011

Pathologic Response of Primary Rectal Cancer to Oxaliplatin-Based Chemotherapy

Por Suárez, Javier, Amat, Irene, Vera, Ruth, Balén, Enrique, Gómez, Marisa, Lera, Jose Miguel
Publicado em 2011

RADICAL SITES IN M. TUBERCULOSIS KATG IDENTIFIED USING EPR SPECTROSCOPY, THE 3-D CRYSTAL STRUCTURE AND ELECTRON-TRANSFER COUPLINGS

Por Ranguelova, Kalina, Girotto, Stefania, Gerfen, Gary J., Yu, Shengwei, Suarez, Javier, Metlitsky, Leonid, Magliozzo, Richard S.
Publicado em 2007

Modulating Enzyme Catalysis through Mutations Designed to Alter Rapid Protein Dynamics

Por Zoi, Ioanna, Suarez, Javier, Antoniou, Dimitri, Cameron, Scott A., Schramm, Vern L., Schwartz, Steven D.
Publicado no J Am Chem Soc (2016)

Role of the Oxyferrous Heme Intermediate and Distal Side Adduct Radical in the Catalase Activity of Mycobacterium tuberculosis KatG Revealed by the W107F Mutant

Por Zhao, Xiangbo, Yu, Shengwei, Ranguelova, Kalina, Suarez, Javier, Metlitsky, Leonid, Schelvis, Johannes P. M., Magliozzo, Richard S.
Publicado em 2009

Specific Function of the Met-Tyr-Trp Adduct Radical and Residues Arg-418 and Asp-137 in the Atypical Catalase Reaction of Catalase-Peroxidase KatG

Por Zhao, Xiangbo, Khajo, Abdelahad, Jarrett, Sanchez, Suarez, Javier, Levitsky, Yan, Burger, Richard M., Jarzecki, Andrzej A., Magliozzo, Richard S.
Publicado em 2012

Catalytic Site Conformations in Human PNP by (19)F-NMR and Crystallography

Por Suarez, Javier, Haapalainen, Antti M., Cahill, Sean M., Ho, Joseph, Yan, Funing, Almo, Steven C., Schramm, Vern L.
Publicado em 2013

Tight binding enantiomers of pre-clinical drug candidates

Por Evans, Gary B., Cameron, Scott A., Luxenburger, Andreas, Guan, Rong, Suarez, Javier, Thomas, Keisha, Schramm, Vern L., Tyler, Peter C.
Publicado no Bioorg Med Chem (2015)

An Oxyferrous Heme/Protein-based Radical Intermediate Is Catalytically Competent in the Catalase Reaction of Mycobacterium tuberculosis Catalase-Peroxidase (KatG)

Por Suarez, Javier, Ranguelova, Kalina, Jarzecki, Andrzej A., Manzerova, Julia, Krymov, Vladimir, Zhao, Xiangbo, Yu, Shengwei, Metlitsky, Leonid, Gerfen, Gary J., Magliozzo, Richard S.
Publicado em 2009

Adjuvant chemotherapy in rectal cancer: defining subgroups who may benefit after neoadjuvant chemoradiation and resection: A pooled analysis of 3313 patients

Por Maas, Monique, Nelemans, Patty J, Valentini, Vincenzo, Crane, Christopher H, Capirci, Carlo, Rödel, Claus, Nash, Garrett M, Kuo, Li-Jen, Glynne-Jones, Rob, García-Aguilar, Julio, Suárez, Javier, Calvo, Felipe A, Pucciarelli, Salvatore, Biondo, Sebastiano, Theodoropoulos, George, Lambregts, Doenja MJ, Beets-Tan, Regina GH, Beets, Geerard L
Publicado no Int J Cancer (2014)