Antibiotic Resistance in Mycobacterium tuberculosis: PEROXIDASE INTERMEDIATE BYPASS CAUSES POOR ISONIAZID ACTIVATION BY THE S315G MUTANT OF M. TUBERCULOSIS CATALASE-PEROXIDASE (KatG)

KatG (catalase-peroxidase) in Mycobacterium tuberculosis is responsible for activation of isoniazid (INH), a pro-drug used to treat tuberculosis infections. Resistance to INH is a global health problem most often associated with mutations in the katG gene. The origin of INH resistance caused by the...

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Autores principales: Suarez, Javier, Ranguelova, Kalina, Schelvis, Johannes P. M., Magliozzo, Richard S.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2009
Materias:
Enzyme Catalysis and Regulation
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2713512/
https://ncbi.nlm.nih.gov/pubmed/19363028
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.005546
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