Three-Dimensional Model and Molecular Mechanism of Mycobacterium tuberculosis Catalase-Peroxidase (KatG) and Isoniazid-Resistant KatG Mutants

Mycobacterium tuberculosis KatG enzyme functions both as catalase for removing hydrogen peroxide (H(2)O(2)) and as peroxidase for oxidating isoniazid (INH) to active form of anti-tuberculosis drug. Although mutations in M. tuberculosis KatG confer INH resistance in tuberculous patients, structural b...

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Main Authors: Mo, L., Zhang, W., Wang, J., Weng, X.H., Chen, S., Shao, L.Y., Pang, M.Y., Chen, Z.W.
Formato: Artigo
Idioma:Inglês
Publicado em: 2004
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2865223/
https://ncbi.nlm.nih.gov/pubmed/15650370
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/mdr.2004.10.269
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