Isoniazid-resistance conferring mutations in Mycobacterium tuberculosis KatG: Catalase, peroxidase, and INH-NADH adduct formation activities

Mycobacterium tuberculosis catalase-peroxidase (KatG) is a bifunctional hemoprotein that has been shown to activate isoniazid (INH), a pro-drug that is integral to frontline antituberculosis treatments. The activated species, presumed to be an isonicotinoyl radical, couples to NAD(+)/NADH forming an...

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Hlavní autoři: Cade, Christine E, Dlouhy, Adrienne C, Medzihradszky, Katalin F, Salas-Castillo, Saida Patricia, Ghiladi, Reza A
Médium: Artigo
Jazyk:Inglês
Vydáno: Wiley Subscription Services, Inc., A Wiley Company 2010
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2866272/
https://ncbi.nlm.nih.gov/pubmed/20054829
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pro.324
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