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Isoniazid Activation Defects in Recombinant Mycobacterium tuberculosis Catalase-Peroxidase (KatG) Mutants Evident in InhA Inhibitor Production

Mycobacterium tuberculosis KatG catalyzes the activation of the antitubercular agent isoniazid to yield an inhibitor targeting enoyl reductase (InhA). However, no firm biochemical link between many KatG variants and isoniazid resistance has been established. In the present study, six distinct KatG v...

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Autori principali: Wei, Chih-Jen, Lei, Benfang, Musser, James M., Tu, Shiao-Chun
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology 2003
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC151726/
https://ncbi.nlm.nih.gov/pubmed/12543676
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.47.2.670-675.2003
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