Isoniazid Activation Defects in Recombinant Mycobacterium tuberculosis Catalase-Peroxidase (KatG) Mutants Evident in InhA Inhibitor Production

Mycobacterium tuberculosis KatG catalyzes the activation of the antitubercular agent isoniazid to yield an inhibitor targeting enoyl reductase (InhA). However, no firm biochemical link between many KatG variants and isoniazid resistance has been established. In the present study, six distinct KatG v...

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Dades bibliogràfiques

Publicat a:	Antimicrob Agents Chemother
Autors principals:	Wei, Chih-Jen, Lei, Benfang, Musser, James M., Tu, Shiao-Chun
Format:	Artigo
Idioma:	Inglês
Publicat:	American Society for Microbiology (ASM) 2003
Matèries:	Mechanisms of Resistance
Accés en línia:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC151726/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12543676/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/AAC.47.2.670-675.2003
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