Isoniazid-resistance conferring mutations in Mycobacterium tuberculosis KatG: Catalase, peroxidase, and INH-NADH adduct formation activities

Mycobacterium tuberculosis catalase-peroxidase (KatG) is a bifunctional hemoprotein that has been shown to activate isoniazid (INH), a pro-drug that is integral to frontline antituberculosis treatments. The activated species, presumed to be an isonicotinoyl radical, couples to NAD(+)/NADH forming an...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Cade, Christine E, Dlouhy, Adrienne C, Medzihradszky, Katalin F, Salas-Castillo, Saida Patricia, Ghiladi, Reza A
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Wiley Subscription Services, Inc., A Wiley Company 2010
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC2866272/
https://ncbi.nlm.nih.gov/pubmed/20054829
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pro.324
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