Role of the Oxyferrous Heme Intermediate and Distal Side Adduct Radical in the Catalase Activity of Mycobacterium tuberculosis KatG Revealed by the W107F Mutant

Catalase-peroxidase (KatG) is essential in Mycobacterium tuberculosis for oxidative stress management and activation of the antitubercular pro-drug isoniazid. The role of a unique distal side adduct found in KatG enzymes, involving linked side chains of residues Met(255), Tyr(229), and Trp(107) (MYW...

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Detalhes bibliográficos
Main Authors: Zhao, Xiangbo, Yu, Shengwei, Ranguelova, Kalina, Suarez, Javier, Metlitsky, Leonid, Schelvis, Johannes P. M., Magliozzo, Richard S.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2009
Assuntos:
Enzyme Catalysis and Regulation
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2652290/
https://ncbi.nlm.nih.gov/pubmed/19139098
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M808107200
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