An Oxyferrous Heme/Protein-based Radical Intermediate Is Catalytically Competent in the Catalase Reaction of Mycobacterium tuberculosis Catalase-Peroxidase (KatG)

A mechanism accounting for the robust catalase activity in catalase-peroxidases (KatG) presents a new challenge in heme protein enzymology. In Mycobacterium tuberculosis, KatG is the sole catalase and is also responsible for peroxidative activation of isoniazid, an anti-tuberculosis pro-drug. Here,...

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Detalhes bibliográficos
Main Authors: Suarez, Javier, Ranguelova, Kalina, Jarzecki, Andrzej A., Manzerova, Julia, Krymov, Vladimir, Zhao, Xiangbo, Yu, Shengwei, Metlitsky, Leonid, Gerfen, Gary J., Magliozzo, Richard S.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2009
Assuntos:
Enzyme Catalysis and Regulation
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2652337/
https://ncbi.nlm.nih.gov/pubmed/19139099
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M808106200
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