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Access channel residues Ser315 and Asp137 in Mycobacterium tuberculosis catalase-peroxidase (KatG) control peroxidatic activation of the pro-drug isoniazid

Peroxidatic activation of the anti-tuberculosis pro-drug isoniazid by Mycobacterium tuberculosis catalase-peroxidase (KatG) is regulated by gating residues of a heme access channel. The steric restriction at the bottleneck of this channel is alleviated by replacement of residue Asp137 with Ser, acco...

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Bibliografski detalji
Glavni autori: Zhao, Xiangbo, Hersleth, Hans-Petter, Zhu, Janan, Andersson, K. Kristoffer, Magliozzo, Richard S.
Format: Artigo
Jezik:Inglês
Izdano: 2013
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3872143/
https://ncbi.nlm.nih.gov/pubmed/24185282
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c3cc47022a
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