RADICAL SITES IN M. TUBERCULOSIS KATG IDENTIFIED USING EPR SPECTROSCOPY, THE 3-D CRYSTAL STRUCTURE AND ELECTRON-TRANSFER COUPLINGS

Catalase-peroxidase (KatG) from Mycobacterium tuberculosis, a Class I peroxidase, exhibits high catalase activity and peroxidase activity with various substrates, and is responsible for activation of the commonly used antitubercular drug, isoniazid (INH). KatG readily forms amino acid based radicals...

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Detalhes bibliográficos
Main Authors: Ranguelova, Kalina, Girotto, Stefania, Gerfen, Gary J., Yu, Shengwei, Suarez, Javier, Metlitsky, Leonid, Magliozzo, Richard S.
Formato: Artigo
Idioma:Inglês
Publicado em: 2007
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1885898/
https://ncbi.nlm.nih.gov/pubmed/17204474
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M607309200
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