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Tight binding enantiomers of pre-clinical drug candidates
MTDIA is a picomolar transition state analogue inhibitor of human methylthioadenosine phosphorylase and a femtomolar inhibitor of E. coli methylthioadenosine nucleosidase. MTDIA has proven to be a non-toxic, orally available pre-clinical drug candidate with remarkable anti-tumour activity against a...
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Publicado no: | Bioorg Med Chem |
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Main Authors: | , , , , , , , |
Formato: | Artigo |
Idioma: | Inglês |
Publicado em: |
2015
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Assuntos: | |
Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4567382/ https://ncbi.nlm.nih.gov/pubmed/26260335 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2015.07.059 |
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