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Tight binding enantiomers of pre-clinical drug candidates
MTDIA is a picomolar transition state analogue inhibitor of human methylthioadenosine phosphorylase and a femtomolar inhibitor of E. coli methylthioadenosine nucleosidase. MTDIA has proven to be a non-toxic, orally available pre-clinical drug candidate with remarkable anti-tumour activity against a...
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| Gepubliceerd in: | Bioorg Med Chem |
|---|---|
| Hoofdauteurs: | , , , , , , , |
| Formaat: | Artigo |
| Taal: | Inglês |
| Gepubliceerd in: |
2015
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| Onderwerpen: | |
| Online toegang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4567382/ https://ncbi.nlm.nih.gov/pubmed/26260335 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2015.07.059 |
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