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Thermodynamic Analysis of Transition State Features in Picomolar Inhibitors of Human 5′ Methylthioadenosine Phosphorylase
Human 5′-methylthioadenosine phosphorylase (MTAP) is solely responsible for 5′-methylthioadenosine (MTA) metabolism to permit S-adenosylmethionine salvage. Transition state (TS) analogues of MTAP are in development as anticancer candidates. TS analogues of MTAP incorporate a cationic nitrogen and a...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2013
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3870587/ https://ncbi.nlm.nih.gov/pubmed/24148083 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi401188w |
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