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Transition State Analogue Inhibitors of 5′-Deoxyadenosine/5′-Methylthioadenosine Nucleosidase from Mycobacterium tuberculosis
Mycobacterium tuberculosis 5′-deoxyadenosine/ 5′-methylthioadenosine nucleosidase (Rv0091) catalyzes the N-riboside hydrolysis of its substrates 5′-methylthioadenosine (MTA) and 5′-deoxyadenosine (5′-dAdo). 5′-dAdo is the preferred substrate, a product of radical S-adenosylmethionine-dependent enzym...
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| Publicado no: | Biochemistry |
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| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6019266/ https://ncbi.nlm.nih.gov/pubmed/28836767 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biochem.7b00576 |
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