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Transition State Analogue Inhibitors of 5′-Deoxyadenosine/5′-Methylthioadenosine Nucleosidase from Mycobacterium tuberculosis

Mycobacterium tuberculosis 5′-deoxyadenosine/ 5′-methylthioadenosine nucleosidase (Rv0091) catalyzes the N-riboside hydrolysis of its substrates 5′-methylthioadenosine (MTA) and 5′-deoxyadenosine (5′-dAdo). 5′-dAdo is the preferred substrate, a product of radical S-adenosylmethionine-dependent enzym...

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Bibliografische gegevens
Gepubliceerd in:Biochemistry
Hoofdauteurs: Namanja-Magliano, Hilda A., Evans, Gary B., Harijan, Rajesh K., Tyler, Peter C., Schramm, Vern L.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2017
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6019266/
https://ncbi.nlm.nih.gov/pubmed/28836767
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biochem.7b00576
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