Mechanism of substrate selection by a highly specific CRISPR endoribonuclease

Por Sternberg, Samuel H., Haurwitz, Rachel E., Doudna, Jennifer A.
Publicado em 2012

Csy4 relies on an unusual catalytic dyad to position and cleave CRISPR RNA

Por Haurwitz, Rachel E, Sternberg, Samuel H, Doudna, Jennifer A
Publicado em 2012

Substrate-specific kinetics of Dicer-catalyzed RNA Processing

Por Chakravarthy, Srinivas, Sternberg, Samuel H., Kellenberger, Colleen, Doudna, Jennifer A.
Publicado em 2010

Conformational control of DNA target cleavage by CRISPR–Cas9

Por Sternberg, Samuel H., LaFrance, Benjamin, Kaplan, Matias, Doudna, Jennifer A.
Publicado no Nature (2015)

Real-time observation of DNA recognition and rejection by the RNA-guided endonuclease Cas9

Por Singh, Digvijay, Sternberg, Samuel H., Fei, Jingyi, Doudna, Jennifer A., Ha, Taekjip
Publicado no Nat Commun (2016)

A conformational checkpoint between DNA binding and cleavage by CRISPR-Cas9

Por Dagdas, Yavuz S., Chen, Janice S., Sternberg, Samuel H., Doudna, Jennifer A., Yildiz, Ahmet
Publicado no Sci Adv (2017)

DNA interrogation by the CRISPR RNA-guided endonuclease Cas9

Por Sternberg, Samuel H., Redding, Sy, Jinek, Martin, Greene, Eric C., Doudna, Jennifer A.
Publicado em 2014

Conformational regulation of CRISPR-associated nucleases

Por Jackson, Ryan N., van Erp, Paul B.G., Sternberg, Samuel H., Wiedenheft, Blake
Publicado no Curr Opin Microbiol (2017)

Translation factors direct intrinsic ribosome dynamics during termination and ribosome recycling

Por Sternberg, Samuel H., Fei, Jingyi, Prywes, Noam, McGrath, Kelly A., Gonzalez, Ruben L.
Publicado no Nat Struct Mol Biol (2009)

Programmable RNA recognition and cleavage by CRISPR/Cas9

Por O’Connell, Mitchell R., Oakes, Benjamin L., Sternberg, Samuel H., East-Seletsky, Alexandra, Kaplan, Matias, Doudna, Jennifer A.
Publicado no Nature (2014)

CasA mediates Cas3-catalyzed target degradation during CRISPR RNA-guided interference

Por Hochstrasser, Megan L., Taylor, David W., Bhat, Prashant, Guegler, Chantal K., Sternberg, Samuel H., Nogales, Eva, Doudna, Jennifer A.
Publicado em 2014

Rational design of a split-Cas9 enzyme complex

Por Wright, Addison V., Sternberg, Samuel H., Taylor, David W., Staahl, Brett T., Bardales, Jorge A., Kornfeld, Jack E., Doudna, Jennifer A.
Publicado no Proc Natl Acad Sci U S A (2015)

Surveillance and processing of foreign DNA by the Escherichia coli CRISPR-Cas system

Por Redding, Sy, Sternberg, Samuel H., Marshall, Myles, Gibb, Bryan, Bhat, Prashant, Guegler, Chantal K., Wiedenheft, Blake, Doudna, Jennifer A., Greene, Eric C.
Publicado no Cell (2015)

A highly-purified, fluorescently-labeled in vitro translation system for single-molecule studies of protein synthesis

Por Fei, Jingyi, Wang, Jiangning, Sternberg, Samuel H., MacDougall, Daniel D., Elvekrog, Margaret M., Pulukkunat, Dileep K., Englander, Michael T., Gonzalez, Ruben L.
Publicado no Methods Enzymol (2010)

High-throughput biochemical profiling reveals sequence determinants of dCas9 off-target binding and unbinding

Por Boyle, Evan A., Andreasson, Johan O. L., Chircus, Lauren M., Sternberg, Samuel H., Wu, Michelle J., Guegler, Chantal K., Doudna, Jennifer A., Greenleaf, William J.
Publicado no Proc Natl Acad Sci U S A (2017)

Structures of Cas9 Endonucleases Reveal RNA-Mediated Conformational Activation

Por Jinek, Martin, Jiang, Fuguo, Taylor, David W., Sternberg, Samuel H., Kaya, Emine, Ma, Enbo, Anders, Carolin, Hauer, Michael, Zhou, Kaihong, Lin, Steven, Kaplan, Matias, Iavarone, Anthony T., Charpentier, Emmanuelle, Nogales, Eva, Doudna, Jennifer A.
Publicado em 2014

A prudent path forward for genomic engineering and germline gene modification

Por Baltimore, David, Berg, Paul, Botchan, Michael, Carroll, Dana, Charo, R. Alta, Church, George, Corn, Jacob E., Daley, George Q., Doudna, Jennifer A., Fenner, Marsha, Greely, Henry T., Jinek, Martin, Martin, G. Steven, Penhoet, Edward, Puck, Jennifer, Sternberg, Samuel H., Weissman, Jonathan S., Yamamoto, Keith R.
Publicado no Science (2015)