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Csy4 relies on an unusual catalytic dyad to position and cleave CRISPR RNA
CRISPR-Cas adaptive immune systems protect prokaryotes against foreign genetic elements. crRNAs derived from CRISPR loci base pair with complementary nucleic acids, leading to their destruction. In Pseudomonas aeruginosa, crRNA biogenesis requires the endoribonuclease Csy4, which binds and cleaves t...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3380207/ https://ncbi.nlm.nih.gov/pubmed/22522703 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2012.107 |
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