Csy4 relies on an unusual catalytic dyad to position and cleave CRISPR RNA

CRISPR-Cas adaptive immune systems protect prokaryotes against foreign genetic elements. crRNAs derived from CRISPR loci base pair with complementary nucleic acids, leading to their destruction. In Pseudomonas aeruginosa, crRNA biogenesis requires the endoribonuclease Csy4, which binds and cleaves t...

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Bibliographic Details
Main Authors: Haurwitz, Rachel E, Sternberg, Samuel H, Doudna, Jennifer A
Format: Artigo
Language:Inglês
Published: Nature Publishing Group 2012
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3380207/
https://ncbi.nlm.nih.gov/pubmed/22522703
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2012.107
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