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Real-time observation of DNA recognition and rejection by the RNA-guided endonuclease Cas9
Binding specificity of Cas9–guide RNA complexes to DNA is important for genome-engineering applications; however, how mismatches influence target recognition/rejection kinetics is not well understood. Here we used single-molecule FRET to probe real-time interactions between Cas9–RNA and DNA targets....
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| Publicado no: | Nat Commun |
|---|---|
| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5027287/ https://ncbi.nlm.nih.gov/pubmed/27624851 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms12778 |
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