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Structural plasticity of PAM recognition by engineered variants of the RNA-guided endonuclease Cas9
The RNA-guided endonuclease Cas9 from Streptococcus pyogenes (SpCas9) forms the core of a powerful genome editing technology. DNA cleavage by SpCas9 is dependent on the presence of a 5’-NGG-3’ protospacer adjacent motif (PAM) in the target DNA, restricting the choice of targetable sequences. To addr...
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| Publicado no: | Mol Cell |
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| Main Authors: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5065715/ https://ncbi.nlm.nih.gov/pubmed/26990992 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2016.02.020 |
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