CasA mediates Cas3-catalyzed target degradation during CRISPR RNA-guided interference

In bacteria, the clustered regularly interspaced short palindromic repeats (CRISPR)–associated (Cas) DNA-targeting complex Cascade (CRISPR-associated complex for antiviral defense) uses CRISPR RNA (crRNA) guides to bind complementary DNA targets at sites adjacent to a trinucleotide signature sequenc...

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Detalhes bibliográficos
Main Authors: Hochstrasser, Megan L., Taylor, David W., Bhat, Prashant, Guegler, Chantal K., Sternberg, Samuel H., Nogales, Eva, Doudna, Jennifer A.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2014
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4020112/
https://ncbi.nlm.nih.gov/pubmed/24748111
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1405079111
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