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A conformational checkpoint between DNA binding and cleavage by CRISPR-Cas9
The Cas9 endonuclease is widely used for genome engineering applications by programming its single-guide RNA, and ongoing work is aimed at improving the accuracy and efficiency of DNA targeting. DNA cleavage of Cas9 is controlled by the conformational state of the HNH nuclease domain, but the mechan...
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| Gepubliceerd in: | Sci Adv |
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| Hoofdauteurs: | , , , , |
| Formaat: | Artigo |
| Taal: | Inglês |
| Gepubliceerd in: |
American Association for the Advancement of Science
2017
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| Onderwerpen: | |
| Online toegang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5547770/ https://ncbi.nlm.nih.gov/pubmed/28808686 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.aao0027 |
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