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Substrate-specific kinetics of Dicer-catalyzed RNA Processing

The specialized ribonuclease Dicer plays a central role in eukaryotic gene expression by producing small regulatory RNAs – miRNAs and siRNAs – from larger double stranded RNA (dsRNA) substrates. Although Dicer will cleave both imperfectly base-paired hairpin structures (pre-miRNAs) and perfect duple...

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書目詳細資料
Main Authors: Chakravarthy, Srinivas, Sternberg, Samuel H., Kellenberger, Colleen, Doudna, Jennifer A.
格式: Artigo
語言:Inglês
出版: 2010
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3005596/
https://ncbi.nlm.nih.gov/pubmed/20932845
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2010.09.030
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