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Substrate-specific kinetics of Dicer-catalyzed RNA Processing
The specialized ribonuclease Dicer plays a central role in eukaryotic gene expression by producing small regulatory RNAs – miRNAs and siRNAs – from larger double stranded RNA (dsRNA) substrates. Although Dicer will cleave both imperfectly base-paired hairpin structures (pre-miRNAs) and perfect duple...
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| Main Authors: | , , , |
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| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
2010
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3005596/ https://ncbi.nlm.nih.gov/pubmed/20932845 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2010.09.030 |
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