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Differential roles of human Dicer-binding proteins TRBP and PACT in small RNA processing

During RNA interference and related gene regulatory pathways, the endonuclease Dicer cleaves precursor RNA molecules to produce microRNAs (miRNAs) and short interfering RNAs (siRNAs). Human cells encode a single Dicer enzyme that can associate with two different double-stranded RNA (dsRNA)-binding p...

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Détails bibliographiques
Auteurs principaux: Lee, Ho Young, Zhou, Kaihong, Smith, Alison Marie, Noland, Cameron L., Doudna, Jennifer A.
Format: Artigo
Langue:Inglês
Publié: Oxford University Press 2013
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3711433/
https://ncbi.nlm.nih.gov/pubmed/23661684
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkt361
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