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Differential roles of human Dicer-binding proteins TRBP and PACT in small RNA processing

During RNA interference and related gene regulatory pathways, the endonuclease Dicer cleaves precursor RNA molecules to produce microRNAs (miRNAs) and short interfering RNAs (siRNAs). Human cells encode a single Dicer enzyme that can associate with two different double-stranded RNA (dsRNA)-binding p...

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Detalhes bibliográficos
Main Authors: Lee, Ho Young, Zhou, Kaihong, Smith, Alison Marie, Noland, Cameron L., Doudna, Jennifer A.
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3711433/
https://ncbi.nlm.nih.gov/pubmed/23661684
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkt361
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