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Differential roles of human Dicer-binding proteins TRBP and PACT in small RNA processing

During RNA interference and related gene regulatory pathways, the endonuclease Dicer cleaves precursor RNA molecules to produce microRNAs (miRNAs) and short interfering RNAs (siRNAs). Human cells encode a single Dicer enzyme that can associate with two different double-stranded RNA (dsRNA)-binding p...

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Hlavní autoři: Lee, Ho Young, Zhou, Kaihong, Smith, Alison Marie, Noland, Cameron L., Doudna, Jennifer A.
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2013
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3711433/
https://ncbi.nlm.nih.gov/pubmed/23661684
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkt361
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