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Dicer–TRBP complex formation ensures accurate mammalian microRNA biogenesis
RNA-mediated gene silencing in human cells requires the accurate generation of ∼22-nucleotide microRNAs (miRNAs) from double-stranded RNA substrates by the endonuclease Dicer. Although the phylogenetically conserved RNA-binding proteins TRBP and PACT are known to contribute to this process, their mo...
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| Опубликовано в: : | Mol Cell |
|---|---|
| Главные авторы: | , , , , , |
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
2014
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4320653/ https://ncbi.nlm.nih.gov/pubmed/25557550 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2014.11.030 |
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