Dicer–TRBP complex formation ensures accurate mammalian microRNA biogenesis

RNA-mediated gene silencing in human cells requires the accurate generation of ∼22-nucleotide microRNAs (miRNAs) from double-stranded RNA substrates by the endonuclease Dicer. Although the phylogenetically conserved RNA-binding proteins TRBP and PACT are known to contribute to this process, their mo...

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Veröffentlicht in:Mol Cell
Hauptverfasser: Wilson, Ross C., Tambe, Akshay, Kidwell, Mary Anne, Noland, Cameron L., Schneider, Catherine P., Doudna, Jennifer A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2014
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4320653/
https://ncbi.nlm.nih.gov/pubmed/25557550
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2014.11.030
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