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Dicer–TRBP complex formation ensures accurate mammalian microRNA biogenesis
RNA-mediated gene silencing in human cells requires the accurate generation of ∼22-nucleotide microRNAs (miRNAs) from double-stranded RNA substrates by the endonuclease Dicer. Although the phylogenetically conserved RNA-binding proteins TRBP and PACT are known to contribute to this process, their mo...
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| 發表在: | Mol Cell |
|---|---|
| Main Authors: | , , , , , |
| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
2014
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4320653/ https://ncbi.nlm.nih.gov/pubmed/25557550 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2014.11.030 |
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