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Functional parameters of Dicer-independent microRNA biogenesis

Until recently, a Dicer-class RNase III enzyme was believed to be essential for microRNA (miRNA) biogenesis in all animals. The conserved vertebrate locus mir-451 defies this expectation and instead matures by direct cleavage of its pre-miRNA hairpin via the Slicer activity of Argonaute2 (Ago2). In...

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Bibliografische gegevens
Hoofdauteurs: Yang, Jr-Shiuan, Maurin, Thomas, Lai, Eric C.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Cold Spring Harbor Laboratory Press 2012
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3334703/
https://ncbi.nlm.nih.gov/pubmed/22461413
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1261/rna.032938.112
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