Conserved vertebrate mir-451 provides a platform for Dicer-independent, Ago2-mediated microRNA biogenesis

Canonical animal microRNAs (miRNAs) are generated by sequential cleavage of precursor substrates by the Drosha and Dicer RNase III enzymes. Several variant pathways exploit other RNA metabolic activities to generate functional miRNAs. However, all of these pathways culminate in Dicer cleavage, sugge...

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Autori principali: Yang, Jr-Shiuan, Maurin, Thomas, Robine, Nicolas, Rasmussen, Kasper D., Jeffrey, Kate L., Chandwani, Rohit, Papapetrou, Eirini P., Sadelain, Michel, O'Carroll, Dónal, Lai, Eric C.
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2010
Soggetti:
Biological Sciences
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2930549/
https://ncbi.nlm.nih.gov/pubmed/20699384
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1006432107
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