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RNase III-independent microRNA biogenesis in mammalian cells

RNase III enzymes are fundamental to the biogenesis of microRNAs (miRNAs) and small interfering RNAs (siRNAs) in all species studied. Although alternative miRNA pathways independent of Drosha or Dicer exist, each still requires one RNase III-type enzyme. Here, we describe two strategies that marry e...

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Bibliographic Details
Main Authors: Maurin, Thomas, Cazalla, Demián, Yang, Jr-Shiuan, Bortolamiol-Becet, Diane, Lai, Eric C.
Format: Artigo
Language:Inglês
Published: Cold Spring Harbor Laboratory Press 2012
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3504669/
https://ncbi.nlm.nih.gov/pubmed/23097423
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1261/rna.036194.112
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