Intertwined pathways for Argonaute-mediated microRNA biogenesis in Drosophila

Although Dicer is essential for general microRNA (miRNA) biogenesis, vertebrate mir-451 is Dicer independent. Instead, its short pre-miRNA hairpin is ‘sliced’ by Ago2, then 3′-resected into mature miRNAs. Here, we show that Drosophila cells and animals generate functional small RNAs from mir-451-typ...

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Bibliographic Details
Main Authors: Yang, Jr-Shiuan, Smibert, Peter, Westholm, Jakub O., Jee, David, Maurin, Thomas, Lai, Eric C.
Format: Artigo
Language:Inglês
Published: Oxford University Press 2014
Subjects:
RNA
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3919586/
https://ncbi.nlm.nih.gov/pubmed/24220090
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkt1038
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