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Intertwined pathways for Argonaute-mediated microRNA biogenesis in Drosophila
Although Dicer is essential for general microRNA (miRNA) biogenesis, vertebrate mir-451 is Dicer independent. Instead, its short pre-miRNA hairpin is ‘sliced’ by Ago2, then 3′-resected into mature miRNAs. Here, we show that Drosophila cells and animals generate functional small RNAs from mir-451-typ...
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| Main Authors: | , , , , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
Oxford University Press
2014
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3919586/ https://ncbi.nlm.nih.gov/pubmed/24220090 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkt1038 |
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