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High-throughput biochemical profiling reveals sequence determinants of dCas9 off-target binding and unbinding
The bacterial adaptive immune system CRISPR–Cas9 has been appropriated as a versatile tool for editing genomes, controlling gene expression, and visualizing genetic loci. To analyze Cas9’s ability to bind DNA rapidly and specifically, we generated multiple libraries of potential binding partners for...
Tallennettuna:
| Julkaisussa: | Proc Natl Acad Sci U S A |
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| Päätekijät: | , , , , , , , |
| Aineistotyyppi: | Artigo |
| Kieli: | Inglês |
| Julkaistu: |
National Academy of Sciences
2017
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| Aiheet: | |
| Linkit: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5448226/ https://ncbi.nlm.nih.gov/pubmed/28495970 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1700557114 |
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