Ezh2-dCas9 and KRAB-dCas9 enable engineering of epigenetic memory in a context-dependent manner

BACKGROUND: Rewriting of the epigenome has risen as a promising alternative to gene editing for precision medicine. In nature, epigenetic silencing can result in complete attenuation of target gene expression over multiple mitotic divisions. However, persistent repression has been difficult to achie...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:Epigenetics Chromatin
Main Authors: O’Geen, Henriette, Bates, Sofie L., Carter, Sakereh S., Nisson, Karly A., Halmai, Julian, Fink, Kyle D., Rhie, Suhn K., Farnham, Peggy J., Segal, David J.
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2019
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6498470/
https://ncbi.nlm.nih.gov/pubmed/31053162
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13072-019-0275-8
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados