Ezh2-dCas9 and KRAB-dCas9 enable engineering of epigenetic memory in a context-dependent manner

BACKGROUND: Rewriting of the epigenome has risen as a promising alternative to gene editing for precision medicine. In nature, epigenetic silencing can result in complete attenuation of target gene expression over multiple mitotic divisions. However, persistent repression has been difficult to achie...

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Publicado en:Epigenetics Chromatin
Main Authors: O’Geen, Henriette, Bates, Sofie L., Carter, Sakereh S., Nisson, Karly A., Halmai, Julian, Fink, Kyle D., Rhie, Suhn K., Farnham, Peggy J., Segal, David J.
Formato: Artigo
Idioma:Inglês
Publicado: BioMed Central 2019
Assuntos:
Research
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6498470/
https://ncbi.nlm.nih.gov/pubmed/31053162
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13072-019-0275-8
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