Bioconjugation of Green Fluorescent Protein via an Unexpectedly Stable Cyclic Sulfonium Intermediate

Por Nathani, Ramiz, Moody, Paul, Smith, Mark E B, Fitzmaurice, Richard J, Caddick, Stephen
Publicado em 2012

A novel synthetic chemistry approach to linkage-specific ubiquitin conjugation

Por Morgan, Rachel E., Chudasama, Vijay, Moody, Paul, Smith, Mark E. B., Caddick, Stephen
Publicado no Org Biomol Chem (2015)

A plug-and-play approach to antibody-based therapeutics via a chemoselective dual click strategy

Por Maruani, Antoine, Smith, Mark E.B., Miranda, Enrique, Chester, Kerry A., Chudasama, Vijay, Caddick, Stephen
Publicado no Nat Commun (2015)

A novel approach to the site-selective dual labelling of a protein via chemoselective cysteine modification

Por Nathani, Ramiz I., Moody, Paul, Chudasama, Vijay, Smith, Mark E. B., Fitzmaurice, Richard J., Caddick, Stephen
Publicado em 2013

A rapid, site-selective and efficient route to the dual modification of DARPins

Por Moody, Paul, Chudasama, Vijay, Nathani, Ramiz I., Maruani, Antoine, Martin, Stephen, Smith, Mark E. B., Caddick, Stephen
Publicado em 2014

Homogeneous Bispecifics by Disulfide Bridging

Por Hull, Elizabeth A., Livanos, Maria, Miranda, Enrique, Smith, Mark E. B., Chester, Kerry A., Baker, James R.
Publicado no Bioconjug Chem (2014)

Bromomaleimide-Linked Bioconjugates Are Cleavable in Mammalian Cells

Por Moody, Paul, Smith, Mark E B, Ryan, Chris P, Chudasama, Vijay, Baker, James R, Molloy, Justin, Caddick, Stephen
Publicado em 2012

Bromopyridazinedione-mediated protein and peptide bioconjugation

Por Chudasama, Vijay, Smith, Mark E. B., Schumacher, Felix F., Papaioannou, Danai, Waksman, Gabriel, Baker, James R., Caddick, Stephen
Publicado em 2011

In Situ Maleimide Bridging of Disulfides and a New Approach to Protein PEGylation

Por Schumacher, Felix F., Nobles, Muriel, Ryan, Chris P., Smith, Mark E. B., Tinker, Andrew, Caddick, Stephen, Baker, James R.
Publicado em 2011

Evaluating the use of Apo-neocarzinostatin as a cell penetrating protein

Por Moody, Paul, Burlina, Fabienne, Martin, Stephen R., Morgan, Rachel E., Offer, John, Smith, Mark E.B., Molloy, Justin E., Caddick, Stephen
Publicado em 2013

Protein Modification, Bioconjugation, and Disulfide Bridging Using Bromomaleimides

Por Smith, Mark E. B., Schumacher, Felix F., Ryan, Chris P., Tedaldi, Lauren M., Papaioannou, Danai, Waksman, Gabriel, Caddick, Stephen, Baker, James R.
Publicado em 2010

Tunable reagents for multi-functional bioconjugation: reversible or permanent chemical modification of proteins and peptides by control of maleimide hydrolysis

Por Ryan, Chris P., Smith, Mark E. B., Schumacher, Felix F., Grohmann, Dina, Papaioannou, Danai, Waksman, Gabriel, Werner, Finn, Baker, James R., Caddick, Stephen
Publicado em 2011

Acid-cleavable thiomaleamic acid linker for homogeneous antibody–drug conjugation

Por Castañeda, Lourdes, Maruani, Antoine, Schumacher, Felix F., Miranda, Enrique, Chudasama, Vijay, Chester, Kerry A., Baker, James R., Smith, Mark E. B., Caddick, Stephen
Publicado em 2013

Next generation maleimides enable the controlled assembly of antibody–drug conjugates via native disulfide bond bridging

Por Schumacher, Felix F., Nunes, João P. M., Maruani, Antoine, Chudasama, Vijay, Smith, Mark E. B., Chester, Kerry A., Baker, James R., Caddick, Stephen
Publicado em 2014

Directed evolution to re-adapt a co-evolved network within an enzyme

Por Strafford, John, Payongsri, Panwajee, Hibbert, Edward G., Morris, Phattaraporn, Batth, Sukhjeet S., Steadman, David, Smith, Mark E.B., Ward, John M., Hailes, Helen C., Dalby, Paul A.
Publicado em 2012

Reversible protein affinity-labelling using bromomaleimide-based reagents

Por Nathani, Ramiz I., Chudasama, Vijay, Ryan, Chris P., Moody, Paul R., Morgan, Rachel E., Fitzmaurice, Richard J., Smith, Mark E. B., Baker, James R., Caddick, Stephen
Publicado em 2013

A platform for efficient, thiol-stable conjugation to albumin's native single accessible cysteine

Por Smith, Mark E. B., Caspersen, Mikael B., Robinson, Eifion, Morais, Maurício, Maruani, Antoine, Nunes, João P. M., Nicholls, Karl, Saxton, Malcolm J., Caddick, Stephen, Baker, James R., Chudasama, Vijay
Publicado no Org Biomol Chem (2015)

Homogeneous antibody fragment conjugation by disulfide bridging introduces ‘spinostics'

Por Schumacher, Felix F., Sanchania, Vishal A., Tolner, Berend, Wright, Zoë V. F., Ryan, Chris P., Smith, Mark E. B., Ward, John M., Caddick, Stephen, Kay, Christopher W. M., Aeppli, Gabriel, Chester, Kerry A., Baker, James R.
Publicado em 2013

A mild synthesis of N-functionalised bromomaleimides, thiomaleimides and bromopyridazinediones()

Por Castañeda, Lourdes, Wright, Zoë V.F., Marculescu, Cristina, Tran, Trang M., Chudasama, Vijay, Maruani, Antoine, Hull, Elizabeth A., Nunes, João P.M., Fitzmaurice, Richard J., Smith, Mark E.B., Jones, Lyn H., Caddick, Stephen, Baker, James R.
Publicado em 2013