A platform for efficient, thiol-stable conjugation to albumin's native single accessible cysteine

Herein we report the use of bromomaleimides for the construction of stable albumin conjugates via conjugation to its native, single accessible, cysteine followed by hydrolysis. Advantages over the classical maleimide approach are highlighted in terms of quantitative hydrolysis and absence of undesir...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:Org Biomol Chem
Main Authors: Smith, Mark E. B., Caspersen, Mikael B., Robinson, Eifion, Morais, Maurício, Maruani, Antoine, Nunes, João P. M., Nicholls, Karl, Saxton, Malcolm J., Caddick, Stephen, Baker, James R., Chudasama, Vijay
Formato: Artigo
Idioma:Inglês
Publicado em: Royal Society of Chemistry 2015
Assuntos:
Chemistry
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4563668/
https://ncbi.nlm.nih.gov/pubmed/26108475
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c5ob01205h
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados