A platform for efficient, thiol-stable conjugation to albumin's native single accessible cysteine

Herein we report the use of bromomaleimides for the construction of stable albumin conjugates via conjugation to its native, single accessible, cysteine followed by hydrolysis. Advantages over the classical maleimide approach are highlighted in terms of quantitative hydrolysis and absence of undesir...

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Библиографические подробности
Опубликовано в: :Org Biomol Chem
Главные авторы: Smith, Mark E. B., Caspersen, Mikael B., Robinson, Eifion, Morais, Maurício, Maruani, Antoine, Nunes, João P. M., Nicholls, Karl, Saxton, Malcolm J., Caddick, Stephen, Baker, James R., Chudasama, Vijay
Формат: Artigo
Язык:Inglês
Опубликовано: Royal Society of Chemistry 2015
Предметы:
Chemistry
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4563668/
https://ncbi.nlm.nih.gov/pubmed/26108475
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c5ob01205h
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