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Cysteine-to-lysine transfer antibody fragment conjugation

The modification of lysine residues with acylating agents has represented a ubiquitous approach to the construction of antibody conjugates, with the resulting amide bonds being robustly stable and clinically validated. However, the conjugates are highly heterogeneous, due to the presence of numerous...

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Bibliografske podrobnosti
izdano v:Chem Sci
Main Authors: Forte, Nafsika, Benni, Irene, Karu, Kersti, Chudasama, Vijay, Baker, James R.
Format: Artigo
Jezik:Inglês
Izdano: Royal Society of Chemistry 2019
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC7066670/
https://ncbi.nlm.nih.gov/pubmed/32190247
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c9sc03825f
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