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Highly homogeneous antibody modification through optimisation of the synthesis and conjugation of functionalised dibromopyridazinediones

Due to their exquisite cysteine-selectivity, excellent stability, and ability to functionally rebridge disulfide bonds, dibromopyridazinediones are emerging as an exciting new class of bioconjugation reagents, particularly in the field of antibody conjugation. Despite this, relatively little work ha...

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Detalhes bibliográficos
Publicado no:Org Biomol Chem
Main Authors: Bahou, Calise, Richards, Daniel A., Maruani, Antoine, Love, Elizabeth A., Javaid, Faiza, Caddick, Stephen, Baker, James R., Chudasama, Vijay
Formato: Artigo
Idioma:Inglês
Publicado em: Royal Society of Chemistry 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6058253/
https://ncbi.nlm.nih.gov/pubmed/29405223
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c7ob03138f
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