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Highly homogeneous antibody modification through optimisation of the synthesis and conjugation of functionalised dibromopyridazinediones

Due to their exquisite cysteine-selectivity, excellent stability, and ability to functionally rebridge disulfide bonds, dibromopyridazinediones are emerging as an exciting new class of bioconjugation reagents, particularly in the field of antibody conjugation. Despite this, relatively little work ha...

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Dettagli Bibliografici
Pubblicato in:Org Biomol Chem
Autori principali: Bahou, Calise, Richards, Daniel A., Maruani, Antoine, Love, Elizabeth A., Javaid, Faiza, Caddick, Stephen, Baker, James R., Chudasama, Vijay
Natura: Artigo
Lingua:Inglês
Pubblicazione: Royal Society of Chemistry 2018
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6058253/
https://ncbi.nlm.nih.gov/pubmed/29405223
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c7ob03138f
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