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One-pot thiol–amine bioconjugation to maleimides: simultaneous stabilisation and dual functionalisation

Maleimide chemistry is widely used in the site-selective modification of proteins. However, hydrolysis of the resultant thiosuccinimides is required to provide robust stability to the bioconjugates. Herein, we present an alternative approach that affords simultaneous stabilisation and dual functiona...

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Pubblicato in:Chem Sci
Autori principali: Wall, Archie, Wills, Alfie G., Forte, Nafsika, Bahou, Calise, Bonin, Lisa, Nicholls, Karl, Ma, Michelle T., Chudasama, Vijay, Baker, James R.
Natura: Artigo
Lingua:Inglês
Pubblicazione: The Royal Society of Chemistry 2020
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC8162801/
https://ncbi.nlm.nih.gov/pubmed/34094388
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/d0sc05128d
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