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One-pot thiol–amine bioconjugation to maleimides: simultaneous stabilisation and dual functionalisation
Maleimide chemistry is widely used in the site-selective modification of proteins. However, hydrolysis of the resultant thiosuccinimides is required to provide robust stability to the bioconjugates. Herein, we present an alternative approach that affords simultaneous stabilisation and dual functiona...
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| 出版年: | Chem Sci |
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| 主要な著者: | , , , , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
The Royal Society of Chemistry
2020
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8162801/ https://ncbi.nlm.nih.gov/pubmed/34094388 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/d0sc05128d |
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