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A Plug-and-Play Platform for the Formation of Trifunctional Cysteine Bioconjugates that also Offers Control over Thiol Cleavability

[Image: see text] Linkers that enable the site-selective synthesis of chemically modified proteins are of great interest to the field of chemical biology. Homogenous bioconjugates often show advantageous pharmacokinetic profiles and consequently increased efficacy in vivo. Cysteine residues have bee...

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Detalhes bibliográficos
Publicado no:Bioconjug Chem
Principais autores: Bahou, Calise, Szijj, Peter A., Spears, Richard J., Wall, Archie, Javaid, Faiza, Sattikar, Afrah, Love, Elizabeth A., Baker, James R., Chudasama, Vijay
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2021
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8154211/
https://ncbi.nlm.nih.gov/pubmed/33710874
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.bioconjchem.1c00057
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