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Highly homogeneous antibody modification through optimisation of the synthesis and conjugation of functionalised dibromopyridazinediones

Due to their exquisite cysteine-selectivity, excellent stability, and ability to functionally rebridge disulfide bonds, dibromopyridazinediones are emerging as an exciting new class of bioconjugation reagents, particularly in the field of antibody conjugation. Despite this, relatively little work ha...

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Xehetasun bibliografikoak
Argitaratua izan da:Org Biomol Chem
Egile Nagusiak: Bahou, Calise, Richards, Daniel A., Maruani, Antoine, Love, Elizabeth A., Javaid, Faiza, Caddick, Stephen, Baker, James R., Chudasama, Vijay
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Royal Society of Chemistry 2018
Gaiak:
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC6058253/
https://ncbi.nlm.nih.gov/pubmed/29405223
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c7ob03138f
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