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Acid-cleavable thiomaleamic acid linker for homogeneous antibody–drug conjugation
In this communication we describe a novel acid-cleavable linker strategy for antibody–drug conjugation. Functional disulfide bridging of the single interchain disulfide bond of a trastuzumab Fab fragment yields a homogeneous antibody–drug conjugate bearing a thiomaleamic acid linker. This linker is...
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| Main Authors: | , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
Royal Society of Chemistry
2013
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3763782/ https://ncbi.nlm.nih.gov/pubmed/23929130 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c3cc45220d |
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