Acid-cleavable thiomaleamic acid linker for homogeneous antibody–drug conjugation

In this communication we describe a novel acid-cleavable linker strategy for antibody–drug conjugation. Functional disulfide bridging of the single interchain disulfide bond of a trastuzumab Fab fragment yields a homogeneous antibody–drug conjugate bearing a thiomaleamic acid linker. This linker is...

Full beskrivning

Sparad:
Bibliografiska uppgifter
Huvudupphovsmän: Castañeda, Lourdes, Maruani, Antoine, Schumacher, Felix F., Miranda, Enrique, Chudasama, Vijay, Chester, Kerry A., Baker, James R., Smith, Mark E. B., Caddick, Stephen
Materialtyp: Artigo
Språk:Inglês
Publicerad: Royal Society of Chemistry 2013
Ämnen:
Chemistry
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3763782/
https://ncbi.nlm.nih.gov/pubmed/23929130
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c3cc45220d
Taggar: Lägg till en tagg
Inga taggar, Lägg till första taggen!

Liknande verk