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Sulfatase-cleavable linkers for antibody-drug conjugates
Antibody-drug conjugates (ADCs) are a class of targeted drug delivery agents combining the cell-selectivity of monoclonal antibodies (mAbs) and the cytotoxicity of small molecules. These two components are joined by a covalent linker, whose nature is critical to the efficacy and safety of the ADC. E...
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| Publicado en: | Chem Sci |
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| Autores principales: | , , , , , |
| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
The Royal Society of Chemistry
2020
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8157321/ https://ncbi.nlm.nih.gov/pubmed/34084399 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c9sc06410a |
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