A general approach for the site-selective modification of native proteins, enabling the generation of stable and functional antibody–drug conjugates

Antibody–drug conjugates (ADCs) are a class of targeted therapeutics that utilize the specificity of antibodies to selectively deliver highly potent cytotoxins to target cells. Although recent years have witnessed significant interest in ADCs, problems remain with the standard linkage chemistries us...

Full beskrivning

Sparad:
Bibliografiska uppgifter
I publikationen:Chem Sci
Huvudupphovsmän: Walsh, Stephen J., Omarjee, Soleilmane, Galloway, Warren R. J. D., Kwan, Terence T.-L., Sore, Hannah F., Parker, Jeremy S., Hyvönen, Marko, Carroll, Jason S., Spring, David R.
Materialtyp: Artigo
Språk:Inglês
Publicerad: Royal Society of Chemistry 2018
Ämnen:
Chemistry
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC6349026/
https://ncbi.nlm.nih.gov/pubmed/30774870
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c8sc04645j
Taggar: Lägg till en tagg
Inga taggar, Lägg till första taggen!

Liknande verk