Efficient development of stable and highly functionalised peptides targeting the CK2α/CK2β protein–protein interaction

The discovery of new Protein–Protein Interaction (PPI) modulators is currently limited by the difficulties associated with the design and synthesis of selective small molecule inhibitors. Peptides are a potential solution for disrupting PPIs; however, they typically suffer from poor stability in viv...

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Veröffentlicht in:Chem Sci
Hauptverfasser: Iegre, Jessica, Brear, Paul, Baker, David J., Tan, Yaw Sing, Atkinson, Eleanor L., Sore, Hannah F., O' Donovan, Daniel H., Verma, Chandra S., Hyvönen, Marko, Spring, David R.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Royal Society of Chemistry 2019
Schlagworte:
Chemistry
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6530537/
https://ncbi.nlm.nih.gov/pubmed/31183056
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c9sc00798a
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