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A fragment-based approach leading to the discovery of a novel binding site and the selective CK2 inhibitor CAM4066
Recently we reported the discovery of a potent and selective CK2α inhibitor CAM4066. This compound inhibits CK2 activity by exploiting a pocket located outside the ATP binding site (αD pocket). Here we describe in detail the journey that led to the discovery of CAM4066 using the challenging fragment...
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| Publicat a: | Bioorg Med Chem |
|---|---|
| Autors principals: | , , , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
Elsevier Science
2017
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5587527/ https://ncbi.nlm.nih.gov/pubmed/28495381 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2017.04.037 |
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